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99% Purity Commercial production 5-CHLORO-2-HYDROXYPYRIMIDINE 54326-16-8 with Cheapest Price
- Molecular Formula: C4H3ClN2O
- Molecular Weight: 130.534
- Appearance/Colour: off-white Solid
- Melting Point: 237-238 °C (decomp)
- Refractive Index: 1.632
- PKA: 7.62±0.10(Predicted)
- PSA： 45.75000
- Density: 1.55 g/cm3/sup>
- LogP: 0.42330
5-CHLORO-2-HYDROXYPYRIMIDINE(Cas 54326-16-8) Usage
InChI:InChI=1/C4H3ClN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)
54326-16-8 Relevant articles
An improved synthesis of [2-14C]2, 5-dichloropyrimidine
Cao, Kai,Tran, Scott B.,Maxwell, Brad D.,Bonacorsi Jr., Samuel J.
, p. 300 - 302 (2012)
A previously described, five-step synthe...
Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection
Beaulieu, Pierre L.,Anderson, Paul C.,Bethell, Richard,B?s, Michael,Bousquet, Yves,Brochu, Christian,Cordingley, Michael G.,Fazal, Gulrez,Garneau, Michel,Gillard, James R.,Kawai, Stephen,Marquis, Martin,McKercher, Ginette,Poupart, Marc-André,Stammers, Timothy,Thavonekham, Bounkham,Wernic, Dominik,Duan, Jianmin,Kukolj, George
, p. 10130 - 10143 (2015/02/05)
The development of interferon-free regim...
VIRAL POLYMERASE INHIBITORS
-
Page/Page column 55, (2010/11/26)
The present invention relates to compoun...
VIRAL POLYMERASE INHIBITORS
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Page/Page column 64, (2010/02/15)
A compound, represented by formula (I) o...
54326-16-8 Process route
-
-
119451-81-9
1-(tert-butyldimethylsilyloxy)methyl-5-chloro-2(1H)-pyrimidinone
-
-
54326-16-8
5-chloropyrimidin-2-one
| Conditions | Yield |
|---|---|
|
With
tetrabutyl ammonium fluoride; silica gel;
In
dichloromethane;
for 4h;
ambient temperature;
|
74%
|
-
-
54326-16-8
5-chloropyrimidin-2-one
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide;
|
54326-16-8 Upstream products
-
119451-81-9
1-(tert-butyldimethylsilyloxy)methyl-5-chloro-2(1H)-pyrimidinone
-
557-01-7
2-hydroxypyrimidine
-
36437-19-1
2-chloromalonaldehyde
-
57-13-6
urea
54326-16-8 Downstream products
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22536-67-0
2,5-dichloropyrimidine
-
103594-88-3
2-(benzyloxy)methoxy-5-chloropyrimidine
-
88045-77-6
1-(benzyloxy)methyl-5-chloro-2(1H)-pyrimidinone
-
144708-15-6
5-chloro-2-phenylsulfenylmethoxypyrimidine
