Factory Supply industrial standard 4-Maleimidobenzoic acid 17057-04-4 In Stock
- Molecular Formula: C11H7NO4
- Molecular Weight: 217.181
- Vapor Pressure: 8.92E-09mmHg at 25°C
- Melting Point: 225-228 °C
- Boiling Point: 447.1 °C at 760 mmHg
- PKA: 3.93±0.10(Predicted)
- Flash Point: 224.2 °C
- PSA： 74.68000
- Density: 1.521 g/cm3
- LogP: 0.87920
4-Maleimidobenzoic acid(Cas 17057-04-4) Usage
|
General Description |
4-Maleimidobenzoic acid is a chemical compound that contains a maleimide functional group and a benzoic acid group. It is commonly used in bioconjugation and crosslinking reactions in chemistry and biochemistry. The maleimide group is reactive towards thiol groups, which makes it useful for linking proteins, peptides, and other biomolecules together. The benzoic acid group also provides additional reactivity and versatility, making 4-Maleimidobenzoic acid a popular choice for modifying and functionalizing biomolecules for various applications in research and industry. Overall, the compound's unique and versatile reactivity make it an important tool in bioconjugation and chemical biology research. |
InChI:InChI=1/C11H7NO4/c13-9-5-6-10(14)12(9)8-3-1-7(2-4-8)11(15)16/h1-6H,(H,15,16)/p-1
17057-04-4 Relevant articles
4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid: X-ray and DFT-calculated structure
Moreno-Fuquen, Rodolfo,Tenorio, Juan C.,Ellena, Javier,De Simone, Carlos A.,Ribeiro, Leandro
, p. o67-o70 (2011)
In the title compound, C11H7NO4, there i...
Covalent conjugation of single-walled carbon nanotube with CYP101 mutant for direct electrocatalysis
Ray, Moumita,Mhaske, Sanjay D.,Haram, Santosh K.,Mazumdar, Shyamalava
, (2021)
Covalent linkage between the single-wall...
Preparation and characterization of new carrier drug polymers based maleimide and its drug release behaviour
Mageed, Fatimah Abdul Razzak,Kareem, Mohanad Musa,Al-Baiati, Mohammad N.
, p. 569 - 574 (2019)
In this work, two new drug substituted m...
Maleimide copolymers containing azobenzene moieties-synthesis and study of liquid crystalline and optical properties
Cozan, Vasile,Hulubei, Camelia,Airinei, Anton,Morariu, Simona
, p. 101900 - 101910 (2016)
New reactive copolymers have been synthe...
Synthesis and evaluation of a novel fluorescent chemosensor for glutathione based on a rhodamine B and N-[4-(carbonyl) phenyl]maleimide conjugate and its application in living cell imaging
Shu, Hai,Wu, Xiaolei,Zhou, Baojing,Han, Yingbin,Jin, Mingjie,Zhu, Jing,Bao, Xiaofeng
, p. 535 - 542 (2017)
A novel rhodamine B spirolactam derivati...
p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors
Correa-Basurto, Jose,Alcantara, Ivan Vazquez,Espinoza-Fonseca, L. Michel,Trujillo-Ferrara, Jose G.
, p. 732 - 735 (2005)
Because Alzheimer's disease (AD) is a me...
A NIR facile, cell-compatible fluorescent sensor for glutathione based on Michael addition induced cascade spirolactam opening and its application in hepatocellular carcinoma
Yang, Xin,Qian, Ying
, p. 7486 - 7494 (2018)
A NIR fluorescence probe with long emiss...
Thermal degradation kinetics and thermodynamics of maleimide-sytrene based alternating copolymer: A comparative investigation of monomer and polymer structures
Ak, Metin,Koyundereli ??lg?, Gülbanu
, (2020)
Thermal degradation of N-(4-(3-Thienyl m...
1,3-dipolar cycloaddition: Free catalytic synthesis and esophageal cancer activity of new 1,2,3-triazole-oxydianiline-maleimide hybrids
Mohammed, Mohammed K.,Almashal, Faeza A.,Jassem, Ahmed M.
, p. 47 - 53 (2021/01/18)
A new series of 1,2,3-triazole-oxydianil...
Synthesis, characterization, and targeted chemotherapy of SCT200-linker-monomethyl auristatin E conjugates
Hu, Xinyue,Jiang, Hailun,Bai, Weiqi,Liu, Xiujun,Miao, Qingfang,Wang, Linlin,Jin, Jie,Cui, Along,Liu, Rui,Li, Zhuorong
supporting information, (2021/03/08)
Antibody-drug conjugates (ADCs) are curr...
17057-04-4 Process route
-
-
108-31-6
maleic anhydride
-
-
150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid
-
-
17057-04-4
N-(4-carboxyphenyl)maleimide
| Conditions | Yield |
|---|---|
|
In
acetone;
at 20 ℃;
for 1h;
Concentration;
Solvent;
|
92%
|
|
In
acetone;
at 20 ℃;
|
82%
|
|
With
acetic acid;
at 100 ℃;
for 3h;
|
82.1%
|
|
maleic anhydride; 4-amino-benzoic acid;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
With
sodium acetate; acetic anhydride;
at 69.84 ℃;
for 2h;
|
60%
|
|
maleic anhydride; 4-amino-benzoic acid;
In
acetone;
at 20 ℃;
for 2h;
With
acetic anhydride;
at 80 ℃;
for 0.5h;
With
sodium acetate;
for 6h;
|
47%
|
|
maleic anhydride; 4-amino-benzoic acid;
In
ethyl acetate;
at 20 ℃;
for 4h;
With
sodium acetate;
In
acetic anhydride;
at 80 ℃;
for 6h;
|
37%
|
|
With
magnesium acetate; acetic anhydride; triethylamine;
In
acetone;
for 0.75h;
Heating;
|
|
|
maleic anhydride; 4-amino-benzoic acid;
In
acetone;
at 20 ℃;
With
magnesium acetate; acetic anhydride; triethylamine;
for 0.75h;
Heating;
|
|
|
With
hydrogenchloride; sodium acetate; acetic anhydride;
In
water; N,N-dimethyl-formamide; acetone;
|
|
|
With
acetic acid;
at 30 - 80 ℃;
for 18h;
Sonication;
|
|
|
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
|
|
|
With
acetic anhydride; triethylamine;
|
|
|
maleic anhydride; 4-amino-benzoic acid;
In
acetone;
at 20 ℃;
for 12h;
With
sodium acetate; acetic anhydride;
In
acetone;
at 80 ℃;
for 0.25h;
|
|
|
With
sodium acetate; acetic anhydride;
In
acetone;
at 20 ℃;
|
|
|
at 170 - 180 ℃;
for 0.166667h;
|
|
|
In
N,N-dimethyl-formamide;
|
|
|
With
2,4,6-trimethyl-pyridine;
In
N,N-dimethyl-formamide;
|
-
-
5432-04-2
N-(4-carboxyphenyl)maleamic acid
-
-
17057-04-4
N-(4-carboxyphenyl)maleimide
| Conditions | Yield |
|---|---|
|
With
sodium acetate; acetic anhydride;
at 80 - 83 ℃;
for 1h;
|
93%
|
|
With
sodium acetate; acetic anhydride;
at 75 ℃;
for 0.166667h;
|
86%
|
|
With
sodium acetate; acetic anhydride;
at 55 - 60 ℃;
for 2h;
|
85%
|
|
With
sodium acetate;
at 80 - 85 ℃;
for 4h;
|
82%
|
|
With
sodium acetate; acetic anhydride;
at 55 - 60 ℃;
for 2h;
|
72%
|
|
With
1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate;
In
1-Propyl acetate;
for 3h;
Reflux;
|
51%
|
|
With
triethylamine;
In
acetic anhydride;
at 60 ℃;
for 1h;
|
47%
|
|
With
sodium acetate; acetic anhydride;
at 90 - 100 ℃;
for 3h;
|
|
|
With
sodium acetate;
In
acetic anhydride;
|
|
|
With
sodium acetate; acetic anhydride;
|
|
|
With
sodium acetate; acetic anhydride;
at 75 ℃;
|
|
|
With
sodium acetate; acetic anhydride;
at 80 ℃;
for 3h;
|
|
|
With
sodium acetate; acetic anhydride;
|
|
|
With
sodium acetate; acetic anhydride;
for 1.5h;
Reflux;
|
|
|
With
sodium acetate; acetic anhydride;
for 0.5h;
Reflux;
|
17057-04-4 Upstream products
-
5432-04-2
4-(3-carboxy-acryloylamino)-benzoic acid
-
150-13-0
4-amino-benzoic acid
-
110-16-7
maleic acid
-
5432-04-2
N-(4-carboxyphenyl)maleamic acid
17057-04-4 Downstream products
-
29305-46-2
4-(2,5-dioxo-2,5-dihydro-1-pyrrol-1-yl)benzoyl chloride
-
64191-06-6
2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
-
97670-49-0
N-Maleoyl-4-aminobenzoesaeure-2,4-dinitrophenylester
-
73431-46-6
N-Maleoyl-4-aminobenzoesaeure-4-nitrophenylester
